OSU:pro

Certifications

2005 - present

Therapeutic Radiologic Physics: American Board of Radiology

Clinical Interests

(1) New Therapy Modalities for Prostate Cancer, Cervical Cancer, Brain Tumors and others.

(2) Intensity-Modulated/Image-Guided Radiation Therapy.

(3) Therapeutic Radiation Physics and Dosimetry.

(4) Particle Therapy.

Degrees

1989	B.S., Tsinghua University, Nuclear Physcs

1991	M.S., Tsinghua University, Nuclear Physics

1995	Ph.D., Chinese Academy of Sciences, Particle Physics

2004	Postdoctoral, University of Maryland, Medical Physics

Editorial Activities

Editor-in-Chief

2006 - present

Associate Editor-in-Chief (10), Senior Editor (06-09), Medjaden Biomedical Ltd.

Editorial Board

2010 - present

American Journal of Translational Research (AJTR).

2009 - present

World Journal of Radiology (WJR).

Peer Reviewer

2009 - present

Journal of Radiological Protection (JRP).

2008 - present

Acta Oncologica.

2008 - present

Journal of Applied Clinical Medical Physics (JACMP).

2006 - present

Arbitrator Reviewer, International Journal of Radiation Biolology (IJRB).

2006 - present

Future Oncology.

2005 - present

Brachytherapy.

2004 - present

Medical Physics (MPH).

2004 - present

Physics in Medicine and Biology (PMB).

2003 - present

International Journal of Radiation Oncology Biology Physics (IJROBP).

2002 - 2003

Nuclear Instruments and Methods (NIM) in Physics Research.

Focus of Research

(1) Radiation Response Modeling

(2) Clinical Data Analysis and Interpretation

(3) New Radiation Technique and Modality Development

(4) Functional Imaging and Therapy Outcome Prediction

(5) RBE of Particle Therapy

Grants

Research Grant

Funded

01/01/1998 - 01/01/2001

"Searching for Antimatter and Cosmic Ray Studies Using BESS." National Aeronautics and Space Administration (NASA), direct cost. Principal Investigator.

01/01/1998 - 01/01/2003

"The Advanced Thin Ionization Calorimeter (ATIC) Experiment." National Aeronautics and Space Administration (NASA). Co-Investigator.

01/01/2001 - 01/01/2004

"Searching for Antimatter and Other Exotics Using BESS." National Aeronautics and Space Administration (NASA), direct cost. Principal Investigator.

07/01/2008 - 07/01/2011

"MR-predictive-assay in pre-operative lung cancer therapy: response/resectability." National Institute of Health. Co-Investigator.

01/01/2010 - 12/31/2011

"Towards Optimal Radiation Therapy: Radiobiological Modeling of Prostate Cancer." Ohio Cancer Research Associates. Principal Investigator.

Honors

1989	First Class Prize of Practice Scholarship of Metal Techniques.

1990	First Class Prize of Guanhua Scholarship.

1990	Third Class Prize of Philosophy Article Competition.

1990	Third Class Prize of Scientific Article Competition for the Anniversary of Tsinghua University.

1991	First Class Prize of Laboratory Development Scholarship.

2002	Antarctica Service Medal of the United States of America.

2003	Finalist (top ten) Selected for the Younger Investigator Competition.

2005	Travel Grant for the First ASTRO Translational Research Symposium.

2007	Excellence in Teaching Award.

2007	Travel Grant for the ASTRO Annual Meeting.

Memberships

1996 - 2002

Member. American Physical Society (APS)

2002 - present

Member. American Association of Physicists in Medicine (AAPM)

2003 - present

Member. American Society of Therapeutic Radiology and Oncology (ASTRO)

2006 - present

Member. Sigma Xi Scientific Research Society

Peer Reviewed Journal Articles

Selected from 72 peer-reviewed journal papers, 3 book chapters and 141 peer-reviewed abstracts or papers in conference proceedings. From. 1991. to.  2010.

Asaoka, Y.; Shikaze, Y.; Abe, K.; Anraku, K.; Fujikawa, M.; Fuke, H.; Haino, S.; Imori, M.; Izumi, K.; Maeno, T.; Makida, Y.; Matsuda, S.; Matsui, N.; Matsukawa, T.; Matsumoto, H.; Matsunaga, H.; Mitchell, J.; Mitsui, T.; Moiseev, A.; Motoki, M.; et al. 2002. Measurements of cosmic-ray low-energy antiproton and proton spectra in a transient period of solar field reversal. Physical Review Letters. Vol. 88, no. 5: 051101/1-4.

Wang, J. Z.; Seo, E. S.; Anraku, K.; Fujikawa, M.; Imori, M.; Maeno, T.; Matsui, N.; Matsunaga, H.; Motoki, M.; Orito, S.; Saeki, T.; Sanuki, T.; Ueda, I.; Yoshimura, K.; Makida, Y.; Suzuki, J.; Tanaka, K.; Yamamoto, A.; Yoshida, T.; Mitsui, T.; et al. 2002. Measurement of cosmic-ray hydrogen and helium and their isotopic composition with the BESS experiment. Astrophysical Journal. Vol. 564, no. 1: 244-59.

Wang, Jian Z; Guerrero, M; Li, X Allen. 2003. Low alpha/beta ratio for prostate cancer: In Response to Dr. Fowler et al. International journal of radiation oncology, biology, physics. Vol. 57, no. 2: 595-596. http://journals.ohiolink.edu/ejc/article.cgi?issn=03603016&issue=v57i0002&article=595_lrfpcirtdfea.

Wang, Jian, Z; Guerrero, M; Li, X Allen. 2003. How low is the alpha/beta ratio for prostate cancer?. International journal of radiation oncology, biology, physics. Vol. 55, no. 1: 194-203.

Wang, Jian, Z; Li, X Allen. 2003. Evaluation of external beam radiotherapy and brachytherapy for localized prostate cancer using equivalent uniform dose. Medical physics. Vol. 30, no. 1: 34-40.

Wang, Jian, Z; Li, X Allen; D'Souza, Warren, D; Stewart, Robert D. 2003. Impact of prolonged fraction delivery times on tumor control: a note of caution for intensity-modulated radiation therapy (IMRT). International journal of radiation oncology, biology, physics. Vol. 57, no. 2: 543-52.

Wang, Jian, Z; Li, X Allen; Yu, Cedric, ; XDiBiase, Steven J. 2003. The low alpha/beta ratio for prostate cancer: what does the clinical outcome of HDR brachytherapy tell us?. International journal of radiation oncology, biology, physics. Vol. 57, no. 4: 1101-8.

Wang, Jian Z; Stewart, Robert D; Carlson, David J; Jennings, Kristofer; Li, X Allen; Guerrero, M. 2005. Reply to "Comments on the 'Comparison of in vitro and in vivo alpha/beta ratios for prostate cancer' ". Physics in medicine and biology. Vol. 50, no. 6: L5-L8. http://journals.ohiolink.edu/ejc/article.cgi?issn=00319155&issue=v50i0006&article=l5_rtooivivrfpc.

Wang, Jian, Z; Li, X Allen. 2005. Impact of tumor repopulation on radiotherapy planning. International journal of radiation oncology, biology, physics. Vol. 61, no. 1: 220-7.

Wang, Jian, Z; Mayr, Nina, A; Li, X Allen; Stewart, Robert D. 2005. Modeling prostate cancer: in regards to Nahum et al. (Int J Radiat Oncol Biol Phys 2003;57:391-401). International journal of radiation oncology, biology, physics. Vol. 61, no. 1: 309-10; author reply 310.

Wang, Jian, Z; Mayr, Nina, A; Yuh, William T C. 2005. Correlation between dose subfractions: in regard to Tome et al. [Radiother Oncol 2004;72:113-114]. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. Vol. 74, no. 3: 347-8.

Wang, Jian, Z; Mayr, Nina, A; Yuh, William T C. 2005. Tumor hypoxia versus blood flow: In regard to Lehtio et al. (Int J Radiat Oncol Biol Phys 2004;59:971-982). International journal of radiation oncology, biology, physics. Vol. 61, no. 5: 1607-8; author reply 1608.

Wang, J, Z; Li, X, A; Mayr, N A. 2006. Dose escalation to combat hypoxia in prostate cancer: a radiobiological study on clinical data. The British journal of radiology. Vol. 79, no. 947: 905-11.

Wang, Jian, Z; Mayr, Nina, A; Nag, Subir; Montebello, Joseph; Gupta, Nilendu; Samsami, Nina; Kanellitsas, Christos. 2006. Effect of edema, relative biological effectiveness, and dose heterogeneity on prostate brachytherapy. Medical physics. Vol. 33, no. 4: 1025-32.

Nag S, Shi PP, Liu B, Gupta N, Bahnson RR, Wang JZ. 2008. Comparison of real-time intraoperative ultrasound-based dosimetry with postoperative CT-based dosimetry for prostate brachytherapy. Int J Radiat Oncol Biol Phys. Vol. 70: 311-317.

Wang JZ, Mayr NA, Yuh WTC. 2008. Behind EUD. [letter]. Acta Oncologica. Vol. 47: 971-972. (IF: 2.274)

Yuan J, Wang JZ, Lo S, Grecula JC, Ammirati M, Montebello JF, Zhang H, Gupta N, Yuh WTC, Mayr NA. 2008. Hypofractionation regimens for stereotactic radiotherapy of large brain tumors. Int J Radiat Oncol Biol Phys. Vol. 72: 390-397.

Wang JZ, Rhee JG, Shi PP, Stewart RD, Li XA. 2008. In vitro determination of radiation sensitivity parameters for DU-145 prostate cancer cells. Int J Radiat Biol. Vol. 84, no. 6. (June): 515-522. (IF: 4.290)

Wang JZ, Mayr NA, Zhang D,Yuh WTC. 2008. MRI for cervical cancer not only correlates with tumor hypoxia, but also predicts ultimate outcome ? In regard to Lim et al. [letter]. Int J Radiat Oncol Biol Phys. Vol. 71, no. 5. (August): 1602-1603. (IF: 4.290)

Mayr NA, Wang JZ, Zhang D, Montebello JF, Grecula JC, Lo SS, Fowler J, Yuh WTC. 2009. Synergistic Effects of Hemoglobin and Tumor Perfusion on Tumor Control and Survival in Cervical Cancer.  Int J Radiat Oncol Biol Phys. Vol. 74: 1513-1521.

Wang JZ, Huang Z. Mayr NA, Yuh WTC. 2009. Behind D||: In Response to Drs. Mavroidis and Lind. [letter].  Acta Oncologica. Vol. 48: 614-617.

Yuh WTC, Mayr NA, Jarjoura D, Wu DH, Grecula JC, Lo SS, Edwards SM, Magnotta VA, Sammet S, Zhang H, Montebello JF, Fowler JM, Knopp MV, Wang JZ. 2009. Predicting control of primary tumor and survival by DCE MRI during Early therapy in cervical cancer.  Invest Radiol. Vol. 44: 343-350.

Huang Z, Mayr NA, Yuh WTC, Lo SS, Montebello JF, Grecula JC, Lu LC, Li K, Zhang H, Gupta N, Wang JZ. 2010. Outcome Prediction of Cervical Cancer: Kinetic Model of Tumor Regression during Radiation Therapy.  Cancer Res. Vol. 70: 463-470.

LO SS, Fakiris AJ, Chang EL, Mayr NA, Wang JZ, Papiez L, Teh BS, McGarry RC, Cardenes HR, Timmerman RD. 2010. Stereotactic body radiation therapy: a novel treatment modality.  Nature Rev Clinl Oncol (formally Nature Clinl Prac Oncol). Vol. 7: 44-54.

Mayr NA, Wang JZ, Lo SS, Zhang D, Grecula JC, Lu L, Montebello JF, Fowler JM, Yuh WTC. 2010. Translating response during therapy into ultimate treatment outcome: a personalized 4-dimensional MRI tumor volumetric regression approach in cervical cancer.  Int J Radiat Oncol Biol Phys. (in press).

Mayr NA, Wang JZ, Zhang D, Grecula JC, Lo SS, Jarjoura D, Montebello JF, Zhang H, Li K, Lu L, Huang Z, Fowler JM, Wu DH, Knopp MV, Yuh WTC. 2010. Longitudinal Changes in Tumor Perfusion Pattern during the Radiation Therapy Course and its Clinical Impact in Cervical Cancer.  Int J Radiat Oncol Biol Phys. (in press).

Wang JZ, Mayr NA, Zhang D, Li K, Grecula JC, Montebello JF, Lo SS, Yuh WTC. 2010. Sequential MR Imaging of Cervical Cancer: Predictive Value of Absolute Tumor Volume and Regression Ratio Measured before, during and after Radiation Therapy.  Cancer. (accepted).

Positions

1995	Guest Scientist, Fermi National Accelerator Laboratory, Cosmic-Ray and Astrophysics Studies with Prof. James W. Cronin, Nobel Laureate. Batavia, IL, United States.

1995 - 2001

Research Associate, University of Maryland, Cosmic-Ray and Space Science Lab. College Park, MD, United States.

2001 - 2004

Postdoctoral Fellow, University of Maryland, Department of Radiation Oncology. Baltimore, MD, United States.

2004	Assistant Professor, University of Oklahoma Health Sciences Center, Department of Radiological Sciences. Oklahoma City, OK, United States.

2005 - 2010

Assistant Professor , The Ohio State University, Radiation Oncology . Columbus, OH, United States.

2004 - present

Assistant Professor, The Ohio State University, Department of Radiation Medicine. Columbus, OH, United States.

2008 - present

Director, Radiation Response Modeling Program, The Ohio State University, Department of Radiation Medicine. Columbus, OH, United States.

Professional Activities

Education

2005 - 2007

Committee Member. Medical Physics Education of Physicians Committee. American Association of Physicists in Medicine (AAPM).

Other

2004 - present

Committee Member. Radiation and Cancer Biology Committee. American Society of Therapeutic Radiology and Oncology (ASTRO).

2007 - present

Committee Member. Research Evaluation Committee. American Society of Therapeutic Radiology and Oncology (ASTRO).

2009 - present

President (2010) President Elect (2009). Ohio River Valley Chapter. American Association of Physicists in Medicine (AAPM).

Research

1999 - 2001

Grant Reviewer. National Aeronautics and Space Administration (NASA).

2007 - present

Grant Reviewer. ASTRO grants, including Junior Faculty Research Award, Resident Research Seed Grant, Basic Science Research Award and various Travel Grants etc.

2009 - present

Grant Reviewer. National Institutes of Health (NIH).

2009 - present

Grant Reviewer. Prostate Cancer Charity Foundation - United Kingdom.

Undergrad., Grad. and Prof. Courses Taught

The Ohio State University, Radiation Biology Radiology 680.

The Ohio State University, Radiation Physics

Summer 2008. The Ohio State University, Radiation Therapy Physics II Rad Tech 482.